Refine your search
Collections
Co-Authors
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Joshi, Yogesh
- Gatifloxacin Induced Dysglycemic Behaviour and Its Impact on Worldwide Patients
Abstract Views :259 |
PDF Views:2
Authors
Affiliations
1 Department of Pharmacology, Himalayan Institute of Pharmacy & Research, Rajawala, Dehradun, Uttarakhand (India), IN
1 Department of Pharmacology, Himalayan Institute of Pharmacy & Research, Rajawala, Dehradun, Uttarakhand (India), IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 5, No 3 (2013), Pagination: 187-190Abstract
Gatifloxacin, a synthetic, novel fluoroquinolone, broad-spectrum antimicrobial agent, is primarily indicated for the treatment of upper respiratory tract infections, urinary tract infections and many more infectious disorders. It acts by inhibiting DNA gyrase and also by inhibiting topoisomerase IV for bacterial infections. Its absolute bioavailability is approximately 96%, extensively distributed into many tissues and body fluids, elimination half-life is approximately 8 hours and major route of elimination is urinary excretion of unchanged drug, with renal clearance accounting for >70%. Approximately 82-88% was recovered in urine as unchanged drug and 6% was recovered in feces. Gatifloxacin was reported to be associated with many serious glycemic abnormalities mostly observed in diabetic as well as in non-diabetic patients. Hypoglycemia usually occurs immediately after the administration while hyperglycemia often takes several days to develop and discontinuation of gatifloxacin treatment markedly improves glucose homeostasis in many cases. It was observed that dysglycemia occurs more frequently in elderly patients, patients with renal insufficiency, diabetic patients, and patients taking medications for diabetics (mainly hypoglycemic agents). One of the study identified that increased gatifloxacin exposure correlates with age-related decreases in renal function and may be responsible for elderly patients being at an increased risk for hyperglycemia. Failure to adjust the dose of gatifloxacin for renal insufficiency has been commonly associated with gatifloxacin-induced hypoglycemia and hyperglycemia. Some researchers observed high incidence rates of hyperglycemia in patients with diabetes compared to those without diabetes while some found no significant difference. Patients receiving glucose lowering medications were at the greatest risk for gatifloxacinassociated hyperglycemic events and patient's not receiving glucoselowering medications also had a significantly increased risk of hyperglycemia. Gatifloxacin is still being used in various parts of the world for treatment of infectious diseases. Therefore, gatifloxacin should be used with caution while undergoing treatment with gatifloxacin.Keywords
Gatifloxacin, Hyperglycemia, Hypoglycemia, Elderly Patients
References
- Tomita T, Onishi M, Sato E, Kimura Y, Kihira K. Gatifloxacin Induces Augmented Insulin Release and Intracellular Insulin Depletion of Pancreatic Islet Cells. Biol Pharm Bull 2007; 30: 644-647.
- Fish DN, North DS. Gatifloxacin, an Advanced 8-Methoxy Fluoroquinolone. Pharmacotherapy 2001; 21: 35-59.
- Tequin (gatifloxacin) [package insert]. Princeton, NJ: Bristol-Myers Squibb Company; January 2006.
- Kendall C, Wooltorton E. People with Diabetes Should Avoid Antibiotic Gatifloxacin. Can Med Ass J 2006; 174: 1089-1090.
- Brennan PJ, Young DB. Gatifloxacin. Tuberculosis 2008; 88(2): 109- 111.
- FDA. Information for Healthcare Professionals. Gatifloxacin (marketed as Tequin) Information. FDA Alert [3/2006]. Available at:http://www.fda.gov/Drugs/DrugSafety/ostmarketDrugSafetyInforma tionforPatients andProviders/ucm107821.htm. Accessed on May 31, 2010.
- Yip C, Lee AJ. Gatifloxacin-Induced Hyperglycemia: A Case Report and Summary of the Current Literature. Clin Ther. 2006; 28: 1857– 1866.
- Tasso L, Bettoni CC, Costa TD. Pharmacokinetic Plasma Profile and Bioavailability Evaluation of Gatifloxacin in Rats. Lat Am J Pharm 2008; 27: 270-273.
- Rubino CM, Capparelli EV, Bradley JS, Blumer JL, Kearns GL, Reed M, Jacobs RF, Cirincione B, Grasela DM. Population Pharmacokinetic Model for Gatifloxacin in Pediatric Patients. Antimicrob Agents Chemother 2007; 51: 1246-1252.
- Jose J, Jimmy B, Saravu K. Dysglycemia Associated With the Use of Fluroquinolones- Focus on Gatifloxacin. J Clin Diagnos Res 2007: 1(3): 185-187.
- Frothingham R. Glucose Homeostasis Abnormalities Associated With the Use of Gatifloxacin. CID 2005; 41: 1269-1276.
- Zvonar R. Gatifloxacin-Induced Dysglycemia. Am J Health Syst Pharm 2006; 63: 2087-2092.
- Park-Wyllie LY, Juurlink DN, Kopp A, Shah BR, Stukel TA, Stumpo C, Dresser L, Low DE, Mamdani MM. Outpatient Gatifloxacin Therapy and Dysglycemia in Older Adults. N Engl J Med 2006; 354: 1352-1361.
- Happe MR, Mulhall BP, Maydonovitch CL, Holtzmuller KC. Gatifloxacin-Induced Hyperglycemia. Ann Intern Med 2004; 141: 968- 969.
- Khovidhunkit W, Sunthornyothin S. Hypoglycemia, Hyperglycemia, and Gatifloxacin. Ann Intern Med 2004; 141: 969.
- Kesavadev J, Rasheed SA. Gatifloxacin Induced Abnormalities in Glucose Homeostasis in a Patient on Glimepiride. J Assoc Physicians India 2006; 54: 951-952.
- Yamada, C, Nagashima, K, Takahashi, A, Ueno, H, Kawasaki, Y, Yamada, Y, Seino, Y, Inagaki, N. Gatifloxacin Acutely Stimulates Insulin Secretion and Chronically Suppresses Insulin Biosynthesis. Eur. J. Pharmacol 2006; 553: 67-72.
- Aspinall SL, Good CB, Jiang R, McCarren M, Dong D, Cunningham FE. Severe Dysglycemia with the Fluoroquinolones: A Class Effect? Clin Infect Dis 2009; 49: 402-408.
- Biggs WS. Hypoglycemia and Hyperglycemia Associated with Gatifloxacin Use in Elderly Patients. J Am Board Fam Pract 2003; 16: 455-457.
- Mohr JF, McKinnon PS, Peymann PJ, Kenton I, Septimus E, Okhuysen PC. A Retrospective, Comparative Evaluation of Dysglycemias in Hospitalized Patients Receiving Gatifloxacin, Levofloxacin, Ciprofloxacin, or Ceftriaxone. Pharmacotherapy 2005; 25: 1303-1309.
- Saraya A, Yokokura M, Gonoi T, Seino S. Effects of Fluoroquinolones on Insulin Secretion and Beta Cell ATP-Sensitive K+ Channels. Eur J Pharmacol 2004; 497: 111-117.
- Ge TF, Law PYP, Wong HY, Ho YY. Gatifloxacin Affects GLUT1 Gene Expression and Disturbs Glucose Homeostasis In-Vitro. Eur J Pharmacol 2007; 573: 70-74.
- Mohr III JF, Peymann PJ, Troxell E, Lodise TP, Ostrosky-Zeichner L. Risk Factors for Hyperglycemia in Hospitalized Adults Receiving Gatifloxacin: A Retrospective, Nested Case-Controlled Analysis. Clin Ther 2008; 30: 152-157.
- Onyenwenyi AJ, Winterstein AG, Hatton RC. An Evaluation of the Effects of Gatifloxacin on Glucose Homeostasis. Pharm World Sci 2008; 30: 544-549.
- Edwards KL, Hall II RG, Ceja ME. Gatifloxacin-Induced Hyperglycemia: A Review of 4 Cases and the Literature. J Pharm Pract 2007; 20: 93-102.
- Owens RC Jr. Fluoroquinolone-Associated Dysglycemias: A Tale of Two Toxicities. Pharmacotherapy 2005; 25: 1291-1295.
- Lodise T, Graves J, Miller C, Mohr JF, Lomaestro B, Smith RP. Effects of Gatifloxacin and Levofloxacin on Rates of Hypoglycemia and Hyperglycemia among Elderly Hospitalized Patients. Pharmacotherapy 2007; 27: 1498-1505.
- Beste LA, Mersfelder TL. Hyperglycemia and Gatifloxacin: A Case Report and Summary of Current Literature. Am J Geriatr Pharmacother 2005; 3: 262-265.
- Donaldson AR, Vandiver JR, Finch CK. Possible Gatifloxacin-Induced Hyperglycemia. Ann Pharmacother 2004; 38: 602-605.
- Blommel AL, Lutes RA. Severe Hyperglycemia During Renally Adjusted Gatifloxacin Therapy. Ann Pharmacother 2005; 39: 1349- 1352.
- Stading JA, Chock AWY, Skrabal MZ, Faulkner MA. Development of Diabetes after Gatifloxacin Therapy. Am J Health Syst Pharm 2005; 62: 2293-2295.
- Baker SE, Hangii MC. Possible Gatifloxacin-Induced Hypoglycemia. Ann Pharmacother 2002; 36: 1722-1726.
- LaPlante KL, Mersfelder TL, Ward KE, Quilliam BJ. Prevalence of and Risk Factors for Dysglycemia in Patients Receiving Gatifloxacin and Levofloxacin in an Outpatient Setting. Pharmacotherapy 2008; 28: 82-89.